The School Nurse Files is about a school nurse An Eun Young (Jeong Yoo Mi), who has the special ability to eradicate ghosts but performs exorcism in an unconventional, comical manner. A mysterious thing takes place at the school and An Eun Young tries to be a good teacher teacher and eradicates the bad ghosts.
Hong In Pyo (Nam Joo Hyuk) is a traditional Korean teacher who is very trapped and walks with obvious limp due to a car accident. He is an influential figure who begins to work in the school founded by his grandfather.